Research

Translational Research Center

MGH is founding the Translational Research Center (TRC) to conduct clinical research trials that derisk new drug and medical device translational opportunities. Under the management of the Translational Management Group, the TRC executes proof-of-concept studies that quickly demonstrate the therapeutic benefit to patients or eliminate compounds with unexpected toxicity or other liabilities

TRC key features:

• In-patient facility on MGH main campus
• 18 to 20 beds, 4 exam rooms, 2 procedure rooms
• Adjacent to the current Clinical Research Center (CRC)
• Expert staff with over 20 years experience in the conduct of complex clinical designs
• Access to research pharmacy, metabolic kitchen, clinical laboratories, & MGH core facilities
• Ready access to state-of-the-art MGH imaging centers
• Core Competencies
• Human Systems Modeling
• Harvard Medical School Systems Biology
• Harvard/MIT Health Sciences & Technology program
• Partners Biobank
• Phenotyping
• Clinical Research Program
• Pathology
• Clinical Research Center
• Harvard Catalyst
• Disease-specific clinical investigators
• Genotyping
• Broad Institute
• Partners Personalized Medicine – CLIA certified genetics lab
• Imaging
• Martinos Center - clinical
• MGH Systems Biology – preclinical animal models
• TMG
• Contract and alliance management
• Clinical trial management
• Data management
• Regulatory Operations
• Clinical Operations

Clinical Trial Designs

• Patient-based studies of molecular mechanism where intensive or novel phenotyping is critical
• Target engagement investigations with PET ligand or state-of-the-art imaging
• Enrichment studies in pre-selected patients based on phenotypic information or genotype recorded in Partners EMR
• Studies to develop biomarkers or new assay read-outs that could be developed in conjunction with an MGH investigator
• Collaborative trials between company scientists and medical investigators that facilitate clinical learning
• Proof-of-concept studies that quickly demonstrate the therapeutic benefit to patients or eliminate compounds with toxicity or other liabilities